- MN 374
I am interested in how pathogenic bacteria cause disease in humans. I am currently collaborating with members of our department in studying mechanisms of iron acquisition by Yersinia pestis. In particular, we are investigating the mechanism of synthesis of the iron siderophore yersiniabactin and its uptake and excretion.
My lab has also been studying the protein toxin, cytolethal distending toxin, which is produced by several Campylobacter species, some Escherichia coli isolates, as well as a few other bacterial pathogens. This toxin was one of the first toxins shown to block the eukaryotic cell cycle. We are interested in the interaction of this toxin with eukaryotic cell components, as well as the regulation, expression and delivery of the toxin by Campylobacter to host cells
Miller, M.C., J.D. Fetherston, C.L. Pickett, A.G. Bobrov, R.H. Weaver, E. DeMoll, and R.D. Perry. 2010. Yersinia pestis irp1-TE and ybtT mutants produce low levels of the Ybt siderophore sufficient to activate transcription of yersiniabactin genes. Microbiology 156:2226-2238.
Pickett, C.L. and R.B. Lee. 2005. The Cytolethal Distending Toxin, In, “Microbial Toxins-Molecular and Cellular Biology”, Horizon Bioscience. Ed., Thomas Proft. Pages 81-97.
Pickett, C.L., R.B. Lee, A. Eyigor, B. Elitzur, E.M. Fox, and N.A. Strockbine. 2004. Patterns of variations in Escherichia coli strains that produce cytolethal distending toxin. Infect. Immun. 72:684-690.
Lee, R.B., D.C. Hassane, D.L. Cottle, and C.L. Pickett. 2003. Campylobacter jejuni cytolethal distending toxin CdtA and CdtC subunit interactions with HeLa cells. Infect. Immun. 71:4883-4890.