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Jamie Sturgill, PhD
jlstur0's picture
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jlstur0@uky.edu
740 S. Limestone L543
Laboratory MN623
Position(s): 
Assistant Professor
Affiliation(s): 
Internal Medicine
Other Affiliation(s): 
Internal Medicine - Pulmonary
Microbiology, Immunology & Molecular Genetics - Adjunct Faculty
Physiology - Joint Faculty
Interests / Specialties: 
Asthma
Intensive care medicine; Acute Respiratory Distress Syndrome (ARDS); Interstitial Lung Disease; Pulmonary Hypertension; Sepsis
Sphingolipids
Bio / Education: 

University of Kentucky BS in Biology
Virginia Commonwealth University Post Baccalaureate Certificate in Microbiology and Immunology
Virginia Commonwealth University PhD Immunology

Selected Publications: 

1. Kim, E.Y*, Sturgill, J.L.*, Hait, N.C., Avni, D., Valencia, E.C., Maceyka, M., Lima, S., Allegood, J., Huang, W.C., Zhang, S., Milstein, S., and Spiegel, S. Role of sphingosine kinase 1 and sphingosine -1-phosphate in CD40 signaling and IgE class switching. FASEB J. 2014 Oct;28(10):4347-4358. PMCID: PMC4202100. *Authors contributed equally.
2. Oyeniran C*, Sturgill JL*, Hait NC, Huang WC, Avni D, Maceyka M, Newton J, AllegoodJC, Montpetit A, Conrad DH, Milstien S, Spiegel S. Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice. J Allergy Clin Immunol. J. Allergy Clin. Immunol. J Allergy Clin Immunol. 2015 Oct;136(4):1035-1046. PMCID: PMC4591101. *Authors contributed equally.
3. Sturgill, JL. Sphingolipids and their enigmatic role in asthma. Adv Biol Regul. 2018 Dec;70:74-81. doi: 10.1016/j.jbior.2018.09.001. Epub 2018 Sep 5.

PubMed Publications: 
  • AA, 3rd Fowler; Truwit, JD ; Hite, RD ; Morris, PE ; DeWilde, C ; Priday, A ; Fisher, B.; LR, 2nd Thacker; Natarajan, R.; Brophy, DF ; Sculthorpe, R ; Nanchal, R ; Syed, A ; Sturgill, J ; Martin, GS ; Sevransky, J ; Kashiouris, M ; Hamman, S ; Egan, KF ; Hastings, A ; Spencer, W ; Tench, S ; Mehkri, O ; Bindas, J ; Duggal, A.; Graf, J ; Zellner, S ; Yanny, L ; McPolin, C ; Hollrith, T ; Kramer, D.; Ojielo, C ; Damm, T ; Cassity, E ; Wieliczko, A ; Halquist, M "Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial." JAMA 322, 13 (2019): 1261-1270. [PubMed Link] | [ Full text ]
  • An, K ; Starkweather, A ; Sturgill, J ; Salyer, J ; Sterling, RK "Association of CTRP13 With Liver Enzymes and Cognitive Symptoms in Nonalcoholic Fatty Liver Disease." Nursing research 68, 1 (2019): 29-38. [PubMed Link] | [ Full text ]
  • Strattan, E ; Palaniyandi, S ; Kumari, R.; Du, J.; Hakim, N ; Huang, T.; Kesler, MV ; Jennings, CD ; Sturgill, JL ; Hildebrandt, GC "Mast Cells Are Mediators of Fibrosis and Effector Cell Recruitment in Dermal Chronic Graft-vs.-Host Disease." Frontiers in immunology 10, (2019): 2470. [PubMed Link] | [ Full text ]
  • Li, SJ ; Vaughan, A.; Sturgill, JF ; Kepecs, A "A Viral Receptor Complementation Strategy to Overcome CAV-2 Tropism for Efficient Retrograde Targeting of Neurons." Neuron 98, 5 (2018): 905-917.e5. [PubMed Link] | [ Full text ]
  • Sturgill, JL "Sphingolipids and their enigmatic role in asthma." Advances in biological regulation 70, (2018): 74-81. [PubMed Link] | [ Full text ]
  • Starkweather, A ; Julian, T ; Ramesh, D.; Heineman, A ; Sturgill, J ; Dorsey, SG ; Lyon, DE ; Wijesinghe, DS "Circulating Lipids and Acute Pain Sensitization: An Exploratory Analysis." Nursing research 66, 6 (2017): 454-461. [PubMed Link] | [ Full text ]
  • Katsuta, E ; Yan, L.; Nagahashi, M ; Raza, A.; Sturgill, JL ; Lyon, DE ; Rashid, OM ; Hait, NC ; Takabe, K "Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer." The Journal of surgical research 219, (2017): 202-213. [PubMed Link] | [ Full text ]
  • Ramanathan, R.; Raza, A.; Sturgill, J ; Lyon, D ; Young, J.; Hait, NC ; Takabe, K "Paradoxical Association of Postoperative Plasma Sphingosine-1-Phosphate with Breast Cancer Aggressiveness and Chemotherapy." Mediators of inflammation 2017, (2017): 5984819. [PubMed Link] | [ Full text ]
  • Robins, JL ; RK, Elswick ; Sturgill, J ; McCain, NL "The Effects of Tai Chi on Cardiovascular Risk in Women." American journal of health promotion : AJHP 30, 8 (2016): 613-622. [PubMed Link] | [ Full text ]
  • Sturgill, J ; Howell, S.; Perry, MM ; Kothari, H "Protocols for treating patients with end-stage renal disease: a survey of undergraduate dental programs." Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry 36, 6 (2016): 321-324. [PubMed Link] | [ Full text ]
  • Starkweather, AR ; Ramesh, D.; Lyon, DE ; Siangphoe, U ; Deng, X.; Sturgill, J ; Heineman, A ; RK, Elswick ; Dorsey, SG ; Greenspan, J "Acute Low Back Pain: Differential Somatosensory Function and Gene Expression Compared With Healthy No-Pain Controls." The Clinical journal of pain 32, 11 (2016): 933-939. [PubMed Link] | [ Full text ]
  • Starkweather, AR ; Lyon, DE ; Kinser, P ; Heineman, A ; Sturgill, JL ; Deng, X.; Siangphoe, U ; Elswick, RK ; Greenspan, J ; Dorsey, SG "Comparison of Low Back Pain Recovery and Persistence: A Descriptive Study of Characteristics at Pain Onset." Biological research for nursing 18, 4 (2016): 401-10. [PubMed Link] | [ Full text ]
  • Kolawole, EM ; McLeod, JJ ; Ndaw, V ; Abebayehu, D ; Barnstein, BO ; Faber, T ; Spence, AJ ; Taruselli, M ; Paranjape, A ; Haque, TT ; Qayum, AA ; Kazmi, QA ; Wijesinghe, DS ; Sturgill, JL ; Chalfant, CE ; Straus, DB ; Oskeritzian, CA ; Ryan, JJ "Fluvastatin Suppresses Mast Cell and Basophil IgE Responses: Genotype-Dependent Effects." Journal of immunology (Baltimore, Md. : 1950) 196, 4 (2016): 1461-70. [PubMed Link] | [ Full text ]
  • Lyon, DE ; Cohen, R.; Chen, H.; Kelly, DL ; McCain, NL ; Starkweather, A ; Ahn, H.; Sturgill, J ; Jackson-Cook, CK "Relationship of systemic cytokine concentrations to cognitive function over two years in women with early stage breast cancer." Journal of neuroimmunology 301, (2016): 74-82. [PubMed Link] | [ Full text ]
  • Austin, KW ; Ameringer, SW ; Starkweather, AR ; Cloud, LJ ; Sturgill, JL ; RK, Elswick "Biobehavioral Framework of Symptom and Health Outcomes of Uncertainty and Psychological Stress in Parkinson Disease." The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses 48, 6 (2016): E2-E9. [PubMed Link] | [ Full text ]
  • Oyeniran, C ; Sturgill, JL ; Hait, NC ; Huang, WC ; Avni, D ; Maceyka, M ; Newton, J ; Allegood, JC ; Montpetit, A.; Conrad, DH ; Milstien, S ; Spiegel, S. "Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice." The Journal of allergy and clinical immunology 136, 4 (2015): 1035-46.e6. [PubMed Link] | [ Full text ]
  • Gage, CC ; Bliven, KC Huxel; Bay, RC ; Sturgill, JS ; Park, JH "Effects of mouthguards on vertical dimension, muscle activation, and athlete preference: a prospective cross-sectional study." General dentistry 63, 6 (2015): 48-55. [PubMed Link] |
  • Dean, L ; Kwon, YJ ; Philpott, MK ; Stanciu, CE ; Seashols-Williams, SJ ; Cruz, Dawson ; Sturgill, J ; Ehrhardt, CJ "Separation of uncompromised whole blood mixtures for single source STR profiling using fluorescently-labeled human leukocyte antigen (HLA) probes and fluorescence activated cell sorting (FACS)." Forensic science international. Genetics 17, (2015): 8-16. [PubMed Link] | [ Full text ]
  • Starkweather, AR ; Coyne, P ; Lyon, DE ; RK, Elswick ; An, K ; Sturgill, J "Decreased low back pain intensity and differential gene expression following CalmareĀ®: results from a double-blinded randomized sham-controlled study." Research in nursing & health 38, 1 (2015): 29-38. [PubMed Link] |
  • Sturgill, J ; Park, JH "Changes in orthodontists' retirement planning and practice operations due to the recent recession." Journal of clinical orthodontics : JCO 49, 4 (2015): 240-8. [PubMed Link] |
  • Sturgill, JF ; Isaacson, JS "Somatostatin cells regulate sensory response fidelity via subtractive inhibition in olfactory cortex." Nature neuroscience 18, 4 (2015): 531-5. [PubMed Link] | [ Full text ]
  • Lyon, D ; McCain, N ; Elswick, RK ; Sturgill, J ; Ameringer, S ; Jallo, N ; Menzies, V ; Robins, J ; Starkweather, A ; Walter, J.; Grap, MJ "Biobehavioral examination of fatigue across populations: report from a P30 Center of Excellence." Nursing outlook 62, 5 (2014): 322-31. [PubMed Link] | [ Full text ]
  • Kim, EY ; Sturgill, JL ; Hait, NC ; Avni, D ; Valencia, EC ; Maceyka, M ; Lima, S.; Allegood, J ; Huang, WC ; Zhang, S.; Milstien, S ; Conrad, D.; Spiegel, S. "Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching." FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28, 10 (2014): 4347-58. [PubMed Link] | [ Full text ]
  • Starkweather, AR ; Sherwood, P.; Lyon, DE ; Bovbjerg, DH ; Broaddus, WC ; RK, Elswick ; Sturgill, J "Depressive symptoms and cytokine levels in Serum and Tumor Tissue in patients with an Astrocytoma: a pilot study." BMC research notes 7, (2014): 423. [PubMed Link] | [ Full text ]
  • Morales, JK ; Saleem, SJ ; Martin, RK ; Saunders, BL ; Barnstein, BO ; Faber, TW ; Pullen, NA ; Kolawole, EM ; Brooks, KB ; Norton, SK ; Sturgill, J ; Graham, L.; Bear, HD ; JF, Urban ; Lantz, CS ; Conrad, DH ; Ryan, JJ "Myeloid-derived suppressor cells enhance IgE-mediated mast cell responses." Journal of leukocyte biology 95, 4 (2014): 643-50. [PubMed Link] | [ Full text ]
  • Sturgill, J ; McGee, E ; Menzies, V "Unique cytokine signature in the plasma of patients with fibromyalgia." Journal of immunology research 2014, (2014): 938576. [PubMed Link] | [ Full text ]
  • Sturgill, JL ; Conrad, DH "Purifying and measuring immunoglobulin E (IgE) and anti-IgE." Methods in molecular biology (Clifton, N.J.) 1032, (2013): 121-31. [PubMed Link] | [ Full text ]
  • Norton, SK ; Wijesinghe, DS ; Dellinger, A.; Sturgill, J ; Zhou, Z.; Barbour, S ; Chalfant, C ; Conrad, DH ; Kepley, CL "Epoxyeicosatrienoic acids are involved in the C(70) fullerene derivative-induced control of allergic asthma." The Journal of allergy and clinical immunology 130, 3 (2012): 761-769.e2. [PubMed Link] | [ Full text ]
  • Saleem, SJ ; Martin, RK ; Morales, JK ; Sturgill, JL ; Gibb, DR ; Graham, L.; Bear, HD ; Manjili, MH ; Ryan, JJ ; Conrad, DH "Cutting edge: mast cells critically augment myeloid-derived suppressor cell activity." Journal of immunology (Baltimore, Md. : 1950) 189, 2 (2012): 511-5. [PubMed Link] | [ Full text ]
  • Swaffar, DS ; Holley, CJ ; Fitch, RW ; Elkin, KR ; Zhang, C.; Sturgill, JP ; Menachery, MD "Phytochemical investigation and in vitro cytotoxic evaluation of alkaloids from Abuta rufescens." Planta medica 78, 3 (2012): 230-2. [PubMed Link] | [ Full text ]
  • Boyd, AM ; Sturgill, JF ; Poo, C ; Isaacson, JS "Cortical feedback control of olfactory bulb circuits." Neuron 76, 6 (2012): 1161-74. [PubMed Link] | [ Full text ]
  • Zhang, Q.; Sturgill, JL ; Kmieciak, M ; Szczepanek, K ; Derecka, M ; Koebel, C.; Graham, LJ ; Dai, Y.; Chen, S.; Grant, S.; Cichy, J ; Shimoda, K ; Gamero, A ; Manjili, M ; Bear, H ; Conrad, D.; Larner, AC "The role of Tyk2 in regulation of breast cancer growth." Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 31, 9 (2011): 671-7. [PubMed Link] | [ Full text ]
  • Suzuki, M.; El-Hage, N.; Zou, S.; Hahn, YK ; Sorrell, ME ; Sturgill, JL ; Conrad, DH ; Knapp, PE ; Hauser, KF "Fractalkine/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death." Molecular neurodegeneration 6, (2011): 78. [PubMed Link] | [ Full text ]
  • Sturgill, JL ; Mathews, J ; Scherle, P ; Conrad, DH "Glutamate signaling through the kainate receptor enhances human immunoglobulin production." Journal of neuroimmunology 233, 1-2 (2011): 80-9. [PubMed Link] | [ Full text ]
  • El-Hage, N.; Podhaizer, EM ; Sturgill, J ; Hauser, KF "Toll-like receptor expression and activation in astroglia: differential regulation by HIV-1 Tat, gp120, and morphine." Immunological investigations 40, 5 (2011): 498-522. [PubMed Link] | [ Full text ]
  • Macey, MR ; Sturgill, JL ; Morales, JK ; Falanga, YT ; Morales, J.; Norton, SK ; Yerram, N ; Shim, H.; Fernando, J.; Gifillan, AM ; Gomez, G.; Schwartz, L ; Oskeritzian, C ; Spiegel, S.; Conrad, D.; Ryan, JJ "IL-4 and TGF-beta 1 counterbalance one another while regulating mast cell homeostasis." Journal of immunology (Baltimore, Md. : 1950) 184, 9 (2010): 4688-95. [PubMed Link] | [ Full text ]
  • Conrad, DH ; Gibb, DR ; Sturgill, J "Regulation of the IgE response." F1000 biology reports 2, (2010): [PubMed Link] | [ Full text ]
  • Sturgill, JF ; Steiner, P ; Czervionke, BL ; Sabatini, BL "Distinct domains within PSD-95 mediate synaptic incorporation, stabilization, and activity-dependent trafficking." The Journal of neuroscience : the official journal of the Society for Neuroscience 29, 41 (2009): 12845-54. [PubMed Link] | [ Full text ]
  • Ford, JW ; Sturgill, JL ; Conrad, DH "129/SvJ mice have mutated CD23 and hyper IgE." Cellular immunology 254, 2 (2009): 124-34. [PubMed Link] | [ Full text ]
  • Conrad, DH ; Ford, JW ; Sturgill, JL ; Gibb, DR "CD23: an overlooked regulator of allergic disease." Current allergy and asthma reports 7, 5 (2007): 331-7. [PubMed Link] |
  • Caven, TH ; Sturgill, JL ; Conrad, DH "BCR ligation antagonizes the IL-21 enhancement of anti-CD40/IL-4 plasma cell differentiation and IgE production found in low density human B cell cultures." Cellular immunology 247, 1 (2007): 49-58. [PubMed Link] | [ Full text ]
  • Weskamp, G ; Ford, JW ; Sturgill, J ; Martin, S.; Docherty, AJ ; Swendeman, S ; Broadway, N ; Hartmann, D ; Saftig, P.; Umland, S ; Sehara-Fujisawa, A ; Black, RA ; Ludwig, A.; Becherer, JD ; Conrad, DH ; Blobel, CP "ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23." Nature immunology 7, 12 (2006): 1293-8. [PubMed Link] | [ Full text ]
  • Yannelli, JR ; Sturgill, J ; Foody, T ; Hirschowitz, E "The large scale generation of dendritic cells for the immunization of patients with non-small cell lung cancer (NSCLC)." Lung cancer (Amsterdam, Netherlands) 47, 3 (2005): 337-50. [PubMed Link] | [ Full text ]
  • Brunet, A ; Sweeney, LB ; Sturgill, JF ; Chua, KF ; Greer, PL ; Lin, Y.; Tran, H.; Ross, SE ; Mostoslavsky, R.; Cohen, HY ; Hu, LS ; Cheng, HL ; Jedrychowski, MP ; Gygi, SP ; Sinclair, DA ; Alt, FW ; Greenberg, ME "Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase." Science (New York, N.Y.) 303, 5666 (2004): 2011-5. [PubMed Link] | [ Full text ]
  • Hirschowitz, EA ; Foody, T ; Kryscio, R.; Dickson, L ; Sturgill, J ; Yannelli, J "Autologous dendritic cell vaccines for non-small-cell lung cancer." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 22, 14 (2004): 2808-15. [PubMed Link] | [ Full text ]
  • , ; Ranger, AM ; Lin, MZ ; Sturgill, JF ; Ma, YC ; Cowan, CW ; Dikkes, P ; Korsmeyer, SJ ; Greenberg, ME "Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis." Developmental cell 3, 5 (2002): 631-43. [PubMed Link] | [ Full text ]
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